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The BIOFIRE System and Your Immune System

The BIOFIRE System provides syndromic infectious disease testing, empowering healthcare providers to select the most appropriate test, the first time. Patients benefit from faster diagnosis and more targeted treatment. Clinicians benefit from improved stewardship of antibiotics. Labs save money and gain efficiency.

The BioFire FilmArray Pneumonia plus panel (PN panel) tests native sputum, endotracheal aspirate, and bronchoalveolar specimens (including mini-BAL) for 33 pathogens that are clinically relevant and antimicrobial resistance genes. The panel provides semiquantitative results within an hour.

Respiratory

The burning of biomass, such as plants, wood and other organic materials, produces gaseous pollution and fine particulates that negatively affect the respiratory system. Furthermore, the environmental issues caused by forest fires, like droughts, could be potentiated by climate change, which can increase the negative effects on the human health.

In the United States wildfire smoke is associated with hospitalizations for respiratory diseases such as asthma, COPD, and lung cancer. This kind of air pollution also increases the risk of developing cardiovascular diseases and is a major cause of the burden on disease among the most vulnerable populations.

During the COVID-19 pandemic, a number of communities were exposed to unhealthy levels of air pollution resulting from wildfires. However the public health response to this environmental issue is sporadic and mainly focused on communicating about symptom management. This knowledge gap is alarming due to the fact that smoking cigarettes and other sources of poor quality air can lead to health issues.

Researchers are currently assessing how to best protect the public's health in the event of future incidents of this type. NIH is funding research on this important public health issue through the BLUE CORAL study and its successor, FIRE CORAL.

For the first time, a prospective study will examine the long-term effects of exposure to smoke from wildfires or other sources. FIRE CORAL is a study that seeks adult participants who are hospitalized for COVID-19 index episodes and speak English or Spanish however, they are not pregnant. The FIRE CORAL protocol includes a set of in-person assessments objectively measuring pulmonary function testing and lung imaging, as well as functional assessments.

Smoke and other particles can cause or worsen respiratory problems like emphysema COPD and pneumonia. Smoke exposure can have adverse effects on your health. To reduce or prevent these negative effects, avoid outdoor activities and use the EPA "N95" mask. This mask is designed to capture small particles.

Smoking cigarettes can cause irritation to the throat, eyes and bio ethanol Fireplace indoor nose. To reduce the symptoms the lungs must be flushed by drinking lots of water and taking medications which reduce inflammation, like corticosteroids.

Bloodstream

Bloodstream is the first line of defense against germs that enter your system. Special cells called dendritic cells are like your fire department's call centre; they gather antigens (molecules that trigger an immune response) from invading germs and then release proteins that signal other white blood cells to fight them. Circulating total white blood cell counts, differentials and band cells were boosted following firefighters' indoor bio ethanol fire-fighting shifts, as compared to levels following physical exertion without firefighting.

Skin

Dermatologists were concerned that smoke and ash from the California wildfires could have negative effects on the skin of those who were exposed to the smoke and ash. Maria Wei, a graduate student at the University of California, Irvine, is studying how extreme wildfire pollution affects the skin. Her research was published in Scientific Reports on April 22.

The study by Wei shows that temperature of the skin changes dependent on the amount of time the body is exposed. It takes upwards of two hours for bio Ethanol fireplace suite a person's skin to reach its flash point--the point at which it burns and turns into a ashy. It is important to avoid staying near a campfire or fire and wear protective clothing if outdoors during a hot or humid day.

Forest fires will continue happen, despite the precautions implemented to reduce the risk of fires from causing pollution. Wei is forecasting that the number of people suffering the effects of wildfires will rise as climate change causes more forests to be burned. That means more people will be required to wear long sleeves, hats, and thick moisturizers.

It's also important to know that atopic dermatitis (itchy skin) which many suffer from can be made worse by wildfire air pollution. The particles in smoke can clog up pores which can cause skin irritation.

Another issue is the fact that atopic dermatitis can make people more sensitive to UV light, which may be aggravated by smoke from wildfires. This makes people more likely to seek out tanning salons and may cause them to tan with less protection than they need to.

A fire and ice treatment could help to reduce atopic dermatitis symptoms however it is not recommended for anyone with an open wound or rash. Those who suffer from acne are advised to avoid it, and if you're pregnant or breastfeeding it is recommended to avoid this treatment altogether. The IS Clinical Fire & Ice Facial at Novuskin, Las Vegas' most prestigious membership MedSpa, is an intensive, results-driven facial that bridges the gap between a mild facial and a peel without needing any downtime. It's designed to smooth skin, reduce rosacea, reduce the appearance of acne scars and fine lines and also stimulate cellular renewal. It's a fantastic treatment to give yourself radiant skin.

Infections

The human body is made up of a complex set of organs and tissue that work together to defend us from infection. Infections are caused by microscopic microorganisms like viruses, bacteria, parasites and fungus that invade healthy cells and cause them to replicate out of control. If this occurs your immune system can respond by displaying symptoms of illness. These symptoms can include a runny nose to an upset stomach and can also include swelling of lymph glands or an itchy scratch. The severity of your symptoms may be affected by the nature of the disease, its location, and Bio Ethanol Fire even your temperature.

Infections can be spread in different ways, but most commonly via droplets of air that remain after a sniff or cough. Bacterial diseases such as tuberculosis and strep throat meningococcal disease and Legionnaires' disease spread in this manner, as do certain viral infections such as the common cold and influenza. Certain infections caused by bacteria, such as skin infections and sexually transmitted diseases (STIs) such as gonorrhea and chlamydia, are spread by contact with infected tissue or mucous membranes or by indirect contact with surfaces that are contaminated. Certain bacterial diseases are carried by bugs like mosquitoes, ticks or fleas. They can be spread by bites from these bugs you.

Infections, parasites, and other microorganisms are small enough that they can enter the bloodstream and cause infection to your cells. This can lead to serious diseases such as the common cold or AIDS. Fungi can cause a variety of skin ailments such as ringworm and athlete's foot, while some are a threat to the lungs and nervous system, such as the rabies virus.

The BioFire Panel utilizes our unique FilmArray Technology to test sputum and bronchoalveolar fluid samples for a comprehensive listing of pathogens that are involved in upper respiratory infections. The kit comes with a reagent kit that contains all the chemistry needed to perform reverse transcription as well as nested multiplex PCR detection with a single machine. It's an easy-to-use solution to help clinicians syndromicly identify and treat patients with various respiratory symptoms. This test has received an Emergency Use Authorization and is available through bioMerieux's CLIA moderate and high-complexity labs.